BI 665915

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

BI 665915 是一种高效、选择性、口服活性的 5-脂氧合酶激活蛋白 (FLAP) 抑制剂，结合 IC50 为 1.7 nM。

BI 665915 is a highly potent, selective, orally active 5-lipoxygenase-activating protein (FLAP) inhibitor with binding IC50 of 1.7 nM; displays no activity against other enzymes and receptors in the leukotriene pathway such as 5-LO, COX-1 and -2, phospholipase A2, LTA4 hydrolase, BLT1, and BLT2 (IC50s>10 uM); shows functional inhibition of LTB4 production in human whole blood (IC50=45 nM); demonstrates a dose-dependent DMPK relationship and inhibition of LTB4 production in vivo.

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BI665915 | BI-665915

Immunology/Inflammation

FLAP

FLAP

Inflammation/Immunology

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1360550-04-4

458.526

C24H26N8O2

>98% (HPLC)

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O=C(N(C)C)CN1N=CC(C2=NC([C@](C3CC3)(C4=CC=C(C5=CN=C(N)N=C5)C=C4)C)=NO2)=C1

2-[4-(3-{(r)-1-[4-(2-amino-pyrimidin-5-yl)-phenyl]-1-cyclopropyl-ethyl}-[1,2,4]oxadiazol-5-yl)-pyrazol-1-yl]-N,N-dimethyl-acetamide

(-20℃)

With Ice Pack

≥ 2 years